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Category: Scientific publication
Automated Filling Equipment Allows Increase in the Maximum Dose to Be Filled in the Cyclops® High Dose Dry Powder Inhalation Device While Maintaining Dispersibility
I. Sibum, P. Hagedoorn, C.O. Botterman, H.W. Frijlink and F. Grasmeijer In recent years there has been increasing interest in the pulmonary delivery of high dose dry powder drugs, such as antibiotics. Drugs in this class need to be dosed in doses far over 2.5 mg, and the use of excipients should therefore be minimized. […]
Characterization and Formulation of Isoniazid for High-Dose Dry Powder Inhalation
I. Sibum, P. Hagedoorn, H.W. Frijlink, F. Grasmeijer International Journal of Pharmaceutics, 2019, 11 (5) (DOI: 10.3390/pharmaceutics11050233)
Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson’s disease
M. Luinstra, A.W.F. Rutgers, T. van Laar, F. Grasmeijer, A. Begeman, V. Isufi, L. Steenhuis, P. Hagedoorn, A.H. de Boer, H.W. Frijlink Pharmacokinetics and tolerability of inhaled levodopa from a new dry-powder inhaler in patients with Parkinson’s disease, Therapeutic Advances in Chronic Disease, 2019, 10 More info
Learning from Parkinson’s patients: Usability of the Cyclops dry powder inhaler
M. Luinstra, V. Isufi, L. de Jong, A.W.F. Rutgers, P. Hagedoorn, J. Puttenstein, T. van Laar, H.W. Frijlink International Journal of Pharmaceutics, 2019, 567, p. 1-5 https://doi.org/10.1016/j.ijpharm.2019.118493